| Action of the Selenomorpholine Compounds on the Bacterium Growth by Microcalorimetry |
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| 作者姓名： | 李曦 刘义 |
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| 作者单位： | [1]StateKeyLaboratoryofAdvancedTechnologyforMaterialsSynthesisandProcessing,WuhanUniversityofTechnology,Wuhan,Hubei430070,China [2]DepartmentofChemistry,Wuhanuniversity,Wuhan,Hubei430072 |
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| 基金项目： | theNationalNaturalScienceFoundationofChina (Nos .2 99730 30and 30 170 0 10 )，ChenguangProjectFoundationofWuhan (No .2 0 0 2 5 0 0 10 0 9) |
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| 摘 要： | The action of β-(N-selenomorpholine) ethyl phenyl ketone hydrochloride and 4-(N-selenomorpholine)-2-butanone hydro-chloride on Escherichia coli and Staphylococcus aureus was studied by microcalorimetry,Differences in their capacities to affect the metabolism of this bacterium were observed.The kinetics shows that the selenomorpholine compounds had action on the metabolism process of Escherichia coli and Staphylococcus aureus.The rate constant (k) of the studied bacterium in the presence of the drugs are concentration-dependant.The growth rate constants decrease with an increase in the mass of the selenomorpholine compounds ,but their relationship is different.As deduced from the rate constant(k) of the studied bacterium(in log phase )and the half inhibitory concentration (IC50),the experimental results reveal that the studied selenomorpholine compounds all have good antibiotic activity and better antibacterial activity on Staphylcoccus aureus than on Escherichia coli.
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| 关 键 词： | 硒基吗啉化合物 细菌生长 微量热法 抗菌活性 抑制作用 |
Action of the Selenomorpholine Compounds on the Bacterium Growth by Microcalorimetry |
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| Xi Li,Yi Liu,Jun Wu,Song‐Sheng Qu.Action of the Selenomorpholine Compounds on the Bacterium Growth by Microcalorimetry[J].Chinese Journal of Chemistry,2002,20(9):829-833. |
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| Authors: | Xi Li Yi Liu Jun Wu Song‐Sheng Qu |
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| Abstract: | The action of β‐(N‐selenomorpholine) ethyl phenyl ketone hydrochloride and 4‐(N‐selenomorpholine)‐2‐butanone hydrochloride on Escherichia coli and Staphylococcus aureus was studied by microcalorimetry. Differences in their capacities to affect the metabolism of this bacterium were observed. The kinetics shows that the selenomorpholine compounds had action on the metabolism process of Escherichia coli and Staphylococcus aureus. The rate constant (k) of the studied bacterium in the presence of the drugs are concentration‐dependant. The growth rate constants decrease with an increase in the mass of the selenomorpholine compounds, but their relationship is different. As deduced from the rate constant (k) of the studied bacterium (in log phase) and the half inhibitory concentration (IC50), the experimental results reveal that the studied selenomorpholine compounds all have good antibiotic activity and better antibacterial activity on Staphylococcus aureus than on Escherichia coli. |
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| Keywords: | selenomorpholine compounds bacterium metabo lism antibacterial activity microcalorimetry |
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