| Studies on Atropo-Enantioselective Synthesis of the Natural Chiral Axial Biaryls |
| |
| 基金项目： | Supported by NSFC (20172063)，The Major State Basic Research Development Program (Grant
No. G2000077506-A) and The project of Chinese Academy of Sciences. |
| |
| 摘 要： | Ary-aryl bond formation plays an important role in modern organic synthesis. These bonds are very often occurred in natural products such as alkaloids as well as in numerous biologically active parts of pharmaceutical and agrochemical specialties. In addition, they are also the scaffolds of some of the most efficient and selective ligands for asymmetric catalysts, especially when atropisomery is possible. In this report, we report the structure and the enantioselective synthesis of some natura…
|
Studies on Atropo-Enantioselective Synthesis of the Natural Chiral Axial Biaryls |
| |
| Authors: | LIN Guo-qiang |
| |
| Abstract: | Ary-aryl bond formation plays an important role in modem organic synthesis. These bonds are very of ten occurred in natural products such as alkaloids as well as in numerous biologically active parts of pharmaceutical and agrochemical specialties. In addition, they are also the scaffolds of some of the most efficient and selective ligands for asymmetric catalysts, especially when atropisomery is possible.In this report, we report the structure and the enantioselective synthesis of some natural occurring bioactive products. The focus will be Mainly in our recently discovered Ni(0) catalyzed homo-coupling and cross-coupling of aryl halide with coumarinyl mesylates and the enantioselective synthesis of phthalides in the presence of bidentated ligands with up to 99% e.e. |
| |
| Keywords: | Homo-coupling Cross-coupling Phthalides |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
