Novel chiral C2-symmetric multidentate aminophosphine ligands for use in catalytic asymmetric reduction of ketones |
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| Authors: | Ya-Qing Xu Shen-Luan Yu Yan-Yun Li Zhen-Rong Dong Jing-Xing Gao State |
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| Affiliation: | Key Laboratory of Physical Chemistry of Solid Surfaces,National Engineering Laboratory for Green Chemical Productions of Alcohols-Ethers-Esters and Department of Chemistry, College of Chemistry and Chemical Engineering,Xiamen University,Xiamen 361005,China |
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| Abstract: | A series of novel chiral C2-symmetric multidentate aminophosphine ligands have been successfully synthesized by Schiff-base condensation of bis(o-formylphenyl)phenylphosphane and easily available monoprotected (1R,2R)-diaminocyclohexane. The catalytic properties of these ligands were investigated in Ir-catalyzed asymmetric transfer hydrogenation of various aromatic ketones, giving the corresponding optical active alcohols with up to 98% conversion and good ee under mild reaction conditions. |
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| Keywords: | Asymmetric catalysis Iridium Aromatic ketones Aminophosphine ligands Asymmetric transfer hydrogenation |
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