Band selective small flip angle COSY: a simple experiment for the analyses of 1H NMR spectra of small chiral molecules

The NMR spectroscopic discrimination of enantiomers in the chiral liquid crystalline solvent is more often carried out using ²H detection in its natural abundance. The employment of ¹H detection for such a purpose is severely hampered due to significant loss of resolution in addition to indistinguishable overlap of the spectra from the two enantiomers. This study demonstrates that the band selected small flip angle homonuclear correlation experiment is a simple and robust technique that provides unambiguous discrimination, very high spectral resolution, reduced multiplicity of transitions, relative signs of the couplings and enormous saving of instrument time.