Theoretical and numerical aspects in the multiphasic modelling of human brain tissue |
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| Authors: | Arndt Wagner Wolfgang Ehlers |
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| Affiliation: | 1. Institute of Applied Mechanics (CE), University of Stuttgart, Pfaffenwaldring 7, 70569 Stuttgart / Germany;2. Institute of Applied Mechanics (CE), University of Stuttgart, Pfaffenwaldring 7, 70569 Stuttgart / Germany Stuttgart Research Centre for Simulation Technology (SRC Simtech), Pfaffenwaldring 5a, 70569 Stuttgart / Germany |
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| Abstract: | A surgical intervention is often required if the functionality of the sensitive human brain tissue is seriously compromised, e. g., due to the occurrence of malignant brain tumours. A promising method for an effective tumour-treatment procedure is given by the so-called convection-enhanced drug delivery (CED), cf. [1]. In this regard, the aim of this contribution is to simulate the expected effects as well as coupled impacts of a (scheduled) CED-procedure with the help of numerical computations, which base on a sophisticated multiphasic and multi-physical modelling strategy applied to human brain tissue. In particular, a quaternary porous-media model, cf. [3–5], is used for the discussion of selected numerical examples and demonstrates the applicability of the model. In detail, the optimal catheter placement and the application of multiple infusion catheters are studied in terms of the occurring anisotropic therapeutic spreading of the infused drug. (© 2015 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim) |
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