Isoquinoline derivatives |
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Authors: | A L Mndzhoyan É A Markaryan Zh S Arustamyan É S Marashyan |
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Institution: | (1) Institute of Precision Organic Chemistry, Academy of Sciences of the Armenian SSR, Erevan |
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Abstract: | 1-(3,4-Dimethoxyphenyl)-1-aminomethylcyclopentane (IV) was condensed with substituted phenylacetyl and benzpyl chlorides to synthesize 1-R ,R ,R -phenylacet(benz)amidomethyl]-1-(3,4-dimethoxyphenyl)cyclopentanes (VI), which were converted to 1-R ,R ,R -phenyl(benzyl)]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-4-spirocyclopentanes (IX) by cyclization and subsequent reduction. Reduction of VI yielded the corresponding secondary amines (VII). The compounds obtained were subjected to Chromatographic analysis. The IR spectra were investigated. Compounds VII and IX were subjected to pharmacological testing.See 6] for communication IV.Deceased.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 637–640, May, 1971. |
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