Synthesis of possible metabolites of chlorpromazine. I. 7-hydroxy derivatives of chlorpromazine,nor1-chlorpromazine and nor2-chlorpromazine |
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Authors: | Edward A. Nodiff Shuichiro Ina Noriichi Oda Takanori Hayazaki Sansei Nishibe Tetsuya Kohno Martin Hausman Albert A. Manian |
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Abstract: | The title compounds and various derivatives have been prepared as analytical standards for the identification of chlorpromazine metabolites in biological materials. Additional evidence is presented for the existence of a halogen-induced Smiles rearrangement in the phenothiazine series. |
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