Catalytic C-H amination for the preparation of substituted 1,2-diamines |
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Authors: | Olson David E Du Bois J |
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Affiliation: | Department of Chemistry, Stanford University, Stanford, California 94305-5080, USA. |
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Abstract: | Rhodium-catalyzed C-H insertion of hydroxylamine-derived sulfamate esters makes possible the synthesis of unique oxathiadiazinane heterocycles, which upon mild reduction furnish differentially substituted 1,2-diamine products. This highly chemo- and diastereoselective transformation underscores the power of catalytic C-H functionalization as a general approach to C-N bond construction. |
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