Isoquinoline derivatives |
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Authors: | É A Markaryan Zh S Arustamyan S S Vasilyan |
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Institution: | (1) A. L. Mndzhoyan Institute of Precision Organic Chemistry, Academy of Sciences of the Armenian SSR, Erevan |
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Abstract: | 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-4-spirocyclopentane was obtained by condensation of 3,4-dimethoxyphenyl-1-(aminomethyl)cyclopentane with formalin. The corresponding amides, which were reduced to tertiary amines, were synthesized by reaction of the latter with the acid chlorides of substituted benzoic and phenylacetic acids. Substituted dibenzoa,-g]quinolizines, isoindolo1,2-a]isoquinolines, and 1-(3,4-dimethoxyphenyl)-1-(6,7-dimethoxy-1, 2,3,4-tetrahydro-2-isoquinolinyl)methyl]cyclopentane were synthesized, respectively, by condensation of 1-aryl (or aralkyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-4-spirocyclopentanes and their open analog -1-(3,4-dimethoxyphenyl)-1-(3,4-dimethoxyphenylethylaminomethyl)cyclopentane — with formalin.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 679–682, May, 1973. |
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