Coulometric titration of penicillins and penicillamine with mercury(II) |
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Authors: | Ulf Forsman |
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Affiliation: | Institute of Chemistry, University of Uppsala, P.O.B. 531, S-751 21 UppsalaSweden |
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Abstract: | An absolute coulometric method based on the titration of hydrolysed penicillins with coulometrically generated mercury(II) is presented. An amalgamated gold plate is used as anode and the titration is performed in a pH 4.6 acetate buffer solution. The method gives values which deviate by less than 1% from values obtained by other absolute methods. The relative standard deviation for determination of penicillin G is 0.4%. The determinations of penicillamine and mixtures of penicillamine and penicilloate are also reported. |
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