| 毛细管电泳-电化学检测法用于生物碱电离常数线性模型的研究 |
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| 引用本文： | 张兰,陈国南,方禹之.毛细管电泳-电化学检测法用于生物碱电离常数线性模型的研究[J].化学学报,2004,62(10):975-978. |
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| 作者姓名： | 张兰 陈国南 方禹之 |
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| 作者单位： | 福州大学化学系,福州,350002;华东师范大学化学系,上海,200062 |
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| 基金项目： | 中国博士后科学基金，福建省自然科学基金 (No .F0 2 1 0 0 0 4 )，福建省教育厅科技发展基金 (No.JA0 2 1 4 3)，福州大学博士后科学发展基金 (No.XJBH 0 1 0 2 )资助项目 |
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| 摘 要： | 依据毛细管区带电泳的特性，推导出在不同pH条件下，有效淌度的倒数(1/μep)与缓冲溶液中氢离子浓度(H^ ])成线性关系，进而建立了用毛细管电泳-电化学检测法测定四种生物碱：苯异丙胺、苯丙醇胺、麻黄碱和甲基麻黄碱电离常数的线性模型和测定方法，测得的pKa值，与紫外分光光度法测定值及文献值比较，结果令人满意．可望在药物离解常数测定的应用中得到推广．
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| 关 键 词： | 毛细管电泳 电化学检测 电离常数 生物碱 |
Study on Ionization Constants of Alkaloids by Linear Model with Capillary Electrophoresis-Electrochemical Detection |
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| ZHANG,Lan a CHEN,Guo Nan,a FANG,Yu Zhi b.Study on Ionization Constants of Alkaloids by Linear Model with Capillary Electrophoresis-Electrochemical Detection[J].Acta Chimica Sinica,2004,62(10):975-978. |
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| Authors: | ZHANG Lan a CHEN Guo Nan a FANG Yu Zhi b |
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| Abstract: | A method based on a linear model for determination of the ionization constants (p K a) of some alkaloids (benzedrine/BZD, phenylpropanolamine/PPA, ephedrine/EPD and methylephedrine/MEPD) by capillary zone electrophoresis with electrochemistry detection has been developed. The K a values were obtained from the plots of the reciprocal of effective mobility against the reciprocal of concentration of sodium hydroxide. The p K a values evaluated by this method were consistent with the values by UV, and also agreeable to the literature values. The proposed method was simple, quick and reliable for determination of the ionization constants (p K a) of alkaloids simultaneously. |
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| Keywords: | capillary electrophoresis electrochemical detection ionization constant alkaloid |
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