| 格列美脲治疗的2型糖尿病大鼠的尿液代谢组学研究 |
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| 引用本文： | 牛俊,皮子凤,越皓,刘淑莹. 格列美脲治疗的2型糖尿病大鼠的尿液代谢组学研究[J]. 高等学校化学学报, 2012, 33(10): 2169-2172. DOI: 10.7503/cjcu20120249 |
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| 作者姓名： | 牛俊 皮子凤 越皓 刘淑莹 |
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| 作者单位： | 1. 中国科学院长春应用化学研究所, 长春质谱中心, 长春 130022;2. 中国科学院研究生院, 北京 100049;3. 长春中医药大学, 长春 130117 |
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| 基金项目： | 国家自然科学基金，吉林省科技发展计划，吉林省医药产业发展专项资金 |
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| 摘 要： | 采用快速高分离度液相色谱-质谱技术(RRLC-MS)检测经格列美脲治疗的2型糖尿病大鼠尿液中代谢物的变化, 对糖尿病组、 给药组和健康对照组大鼠的尿液代谢物谱进行了分析. 采用主成分分析(PCA)对3组大鼠进行分类并寻找潜在生物标记物. 结果表明, 3组大鼠的尿液代谢物谱得到了很好的区分, 发现并鉴定了2个潜在生物标记物, 分别为4-脱氧三羟基丁酸和4-胍基丁酸. 格列美脲对2型糖尿病大鼠的药物作用可能体现为对氨基酸代谢的调节作用.
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| 关 键 词： | 2型糖尿病大鼠 代谢组学 快速高分离度液相色谱-质谱 格列美脲 |
| 收稿时间： | 2012-03-21 |
Urinary Metabonomics Study of Type 2 Diabetic Rats Treated by Glimepiride |
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| NIU Jun , PI Zi-Feng , YUE Hao , LIU Shu-Ying. Urinary Metabonomics Study of Type 2 Diabetic Rats Treated by Glimepiride[J]. Chemical Research In Chinese Universities, 2012, 33(10): 2169-2172. DOI: 10.7503/cjcu20120249 |
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| Authors: | NIU Jun PI Zi-Feng YUE Hao LIU Shu-Ying |
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| Affiliation: | 1. Changchun Center of Mass Spectrometry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China;2. Graduate School of the Chinese Academy of Sciences, Beijing 100049, China;3. Changchun University of Chinese Medicine, Changchun 130117, China |
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| Abstract: | A urinary metabonomics method based on rapid resolusion liquid chromatography-mass spectrometry(RRLC-MS) was developed to study the effect mechanism of glimepiride on type 2 diabetes mellitus. With multivariate statistical analysis of urinary metabolite profiles, a clear separation between streptozotocin-induced type 2 diabetic rats and those treated with glimepiride was achieved. Two significantly changed metabolites have been identified and used to explain the mechanism. The results show that the possible effect mechanism of glimepiride on type 2 diabetes is involved in amino acid metabolism. |
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| Keywords: | Type 2 diabetic rat Metabonomics Rapid resolution liquid chromatography-mass spectrometry(RRLC-MS) Glimepiride |
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