Synthesis and absolute stereochemistry of roseophilin |
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| Authors: | Harrington P E Tius M A |
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| Institution: | Department of Chemistry, 2545 The Mall, University of Hawaii, Honolulu, HI 96822, USA. |
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| Abstract: | The enantiospecific total synthesis of natural roseophilin has been completed in 7.0% overall yield over 15 steps by means of an asymmetric cyclopentannelation. This establishes the absolute configuration of the natural product as 22R,23R. Cyclopentenone (+)-12 was prepared in 78% yield and 86% ee in the key step. |
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