INNA for interelement correlations in rats after mercuric chloride exposure |
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| Authors: | L Tandon E J Kasarskis W D Ehmann |
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| Institution: | (1) Department of Chemistry, University of Kentucky, 40506-0055 Lexington, KY, USA;(2) Department of Neurology, University of Kentucky, 40506-0055 Lexington, KY, USA;(3) Department of Toxicology, University of Kentucky, 40506-0055 Lexington, KY, USA |
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| Abstract: | In an animal model study, we exposed rats to mercuric chloride through drinking water continuously for eight to ten months. A group of these rats were then taken off mercuric chloride water and fed distilled water. A control group of rats was given distilled water. Rat brain, spinal cord, and kidney were analyzed to determine Hg and nine other elements by INAA. Significant imbalances were detected among the groups. Most of the mercury (Hg) was found to be eliminated from the tissues studied within the first thirty days. Implications of the data are discussed in light of observed trace element imbalances in amyotrophic lateral sclerosis and Alzheimer's disease. |
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