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Magnetic Resonance Imaging of Rat C6 Glioma Model Enhanced by Using Water-Soluble Gadolinium Fullerene |
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| Authors: | M A Shevtsov B P Nikolaev Ya Yu Marchenko L Y Yakovleva A V Dobrodumov G Török E Pitkin V T Lebedev |
| Institution: | 1. Institute of Cytology of the Russian Academy of Sciences (RAS), Tikhoretsky ave., 4, 194064, St. Petersburg, Russia 2. I.P. Pavlov State Medical University, St. Petersburg, Russia 3. State Research Institute of Highly Pure Biopreparation, St. Petersburg, Russia 4. Institute of Macromolecular Compounds of the Russian Academy of Sciences (RAS), St. Petersburg, Russia 5. Wigner Research Centre of HAS, Research Institute for Solid State Physics and Optics, Budapest, POB-49, Hungary 6. Wharton School, University of Pennsylvania, Philadelphia, PA, USA 7. Institute of Nuclear Physics, St. Petersburg, Russia |
| Abstract: | Water-soluble gadofullerene Gd@Ful with composition Gd3+@C82(OH) X 3– (x ~ 20) was synthesized for theranostic study. Nanosuspensions of Gd@Ful were used for magnetic relaxation measurements in vitro and for magnetic resonance imaging of a rat with intracranially implanted C6 glioma. Gd@Ful was shown to reduce proton relaxation times in vitro and provide dual contrast of T 1- and T 2-weighted images in a rat brain tumor model after paramagnetic intravenous delivery. Magnetic relaxation times of water protons under action of Gd@Ful were strongly shortened due to cluster formation and increase of motional correlation times of protons in the vicinity of the fullerene cage. The Gd@Ful administration promoted the improvement of glioma contrast enhancement at T 2-weighted images due to accumulation of paramagnetic substance at the tumor site. The contrast efficiency of Gd@Ful corresponds to the characteristics of negative contrast agent. The Gd@Ful nanosuspension is shown to be a contrast enhancer with high anti-tumor therapeutic potency. The retention of the Gd@Ful in the tumor resulted in a 75 % increase in survival times of the tumor-bearing animals. |
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