High-performance silicon nanopore hemofiltration membranes |
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Authors: | William H. Fissell Anna Dubnisheva Abigail N. Eldridge Aaron J. Fleischman Andrew L. Zydney Shuvo Roy |
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Affiliation: | 1. Department of Nephrology and Hypertension, Cleveland Clinic, Cleveland, OH 44195, United States;2. Department of Biomedical Engineering, Cleveland Clinic, Cleveland, OH, United States;3. Department of Chemical Engineering, Pennsylvania State University, University Park, PA, United States;4. Department of Bioengineering & Therapeutic Sciences, University of California, San Francisco, CA, United States |
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Abstract: | Silicon micromachining provides the precise control of nanoscale features that can be fundamentally enabling for miniaturized, implantable medical devices. Concerns have been raised regarding blood biocompatibility of silicon-based materials and their application to hemodialysis and hemofiltration. A high-performance ultrathin hemofiltration membrane with monodisperse slit-shaped pores was fabricated using a sacrificial oxide technique and then surface-modified with poly(ethylene glycol) (PEG). Fluid and macromolecular transport matched model predictions well. Protein adsorption, fouling, and thrombosis were significantly inhibited by the PEG. The membrane retained hydraulic permeability and molecular selectivity during a 90-h hemofiltration experiment with anticoagulated bovine whole blood. This is the first report of successful prolonged hemofiltration with a silicon nanopore membrane. The results demonstrate feasibility of renal replacement devices based on these membranes and materials. |
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Keywords: | Hemofiltration Artificial kidney Nanotechnology MEMS Silicon |
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