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Mineralization of biomimetically carboxymethylated collagen fibrils in a model dual membrane diffusion system |
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| Authors: | Hermann Ehrlich Thomas Hanke René Born Christiane Fischer Andrej Frolov Tobias Langrock Ralf Hoffmann Uwe Schwarzenbolz Thomas Henle Paul Simon Dorin Geiger Vasily V Bazhenov Hartmut Worch |
| Institution: | 1. Max Bergmann Centre of Biomaterials and Institute of Materials Science, Technische Universitaet Dresden, 01069 Dresden, Germany;2. Institute of Food Chemistry, Technische Universitaet Dresden, 01062 Dresden, Germany;3. Institute of Bioanalytical Chemistry, Center for Biotechnology and Biomedicine, Universität Leipzig, 04103 Leipzig, Germany;4. Max Planck Institute of Chemical Physics of Solids, D-01187 Dresden, Germany;5. Speziallabor Triebenberg, Zum Triebenberg 50, D-01328 Dresden (Zaschendorf), Germany;6. Institute of Chemistry and Applied Ecology, Far Eastern National University, 690650 Vladivostok, Russia |
| Abstract: | In the present work, we show for the first time, that N?-carboxymethyllysine is the major product of the in vitro non-enzymatic glycation reaction between fibrillar collagen and glucuronic acid. Dual diffusion membrane system was effectively used for oriented crystal growth of octacalcium phosphate/hydroxyapatite on the biomimetically carboxymethylated collagen fibrils. We hypothesize that the function of biomimetically carboxymethylated collagen is to increase the local concentration of corresponding ions in such a way that a critical nucleus of ions can be formed, leading to the formation of the mineral under specific micro-environment conditions achieved by using diffusion membrane system. |
| Keywords: | Dual membrane diffusion system Collagen Carboxymethyllysine Calcium phosphate phases |
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