Synthesis of the C22-C26 tetrahydropyran segment of phorboxazole by a stereoselective prins cyclization |
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| Authors: | Rychnovsky Thomas |
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| Institution: | Department of Chemistry, University of California, Irvine 92697-2020, USA. srychnov@uci.edu |
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| Abstract: | formula: see text] Tetrahydropyran rings are found in many complex natural products, and the segment-coupling Prins cyclization is an effective strategy for their synthesis. We report a four-step, stereoselective synthesis of the C20-C27 tetrahydropyran segment of phorboxazole. The key step is a Prins cyclization induced by catalytic BF3.OEt2. |
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