Novel molecular drug carrier: encapsulation of oxaliplatin in cucurbit[7]uril and its effects on stability and reactivity of the drug |
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Authors: | Jeon Young Jin Kim Soo-Young Ko Young Ho Sakamoto Shigeru Yamaguchi Kentaro Kim Kimoon |
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Institution: | National Creative Research Initiative Center for Smart Supramolecules, Division of Molecular and Life Sciences, Pohang University of Science and Technology San 31 Hyojadong, Pohang 790-784, Republic of Korea. |
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Abstract: | Oxaliplatin forms a stable 1:1 inclusion complex with cucurbit7]uril as indicated by NMR, mass spectrometry, isothermal titration calorimetry and X-ray crystallography. The encapsulation of the drug results in a large enhancement in stability, a moderate decrease in reactivity toward guanosine but a much larger decrease in reactivity toward L-methionine, which suggests the encapsulation not only increases the stability of the drug but also may reduce unwanted side effects caused by protein binding of the platinum drug. A preliminary in vitro assay using various tumor cell lines reveals that the encapsulation results in a decrease in the antitumor activity of oxaliplatin. |
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