Preparation of Cu(OAc)2/MCM‐41 catalyst and its application in the one‐pot synthesis of 1,2,3‐triazoles in water

An efficient one‐pot synthesis of 1,2,3‐triazoles via the three‐component coupling reaction between benzyl or alkyl bromides, terminal alkynes, and sodium azide in the presence of catalytic amounts of Cu(OAc)₂/MCM‐41 catalyst has been described. This catalyst showed high catalytic activity and 1,4‐regioselectivity for the 3 + 2]Huisgen cycloaddition. This method avoids isolation and handling of organic azides, using water as a solvent, and catalyst recycling makes this synthesis a truly green procedure. © 2012 Wiley Periodicals, Inc. Heteroatom Chem 23:415–421, 2012; View this article online at wileyonlinelibrary.com . DOI 10.1002/hc.21031