Design and recognition of cucurbituril-secured platinum-bound oligopeptides |
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Authors: | Hé ctor Barbero,Eric Masson |
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Affiliation: | Department of Chemistry and Biochemistry, Ohio University, Athens Ohio 45701 USA, |
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Abstract: | Platinum terpyridyl complexes, stacked on top of one another and secured as dimers with cucurbit[8]uril (CB[8]) in aqueous medium, were functionalized quantitatively and in situ with a pair of pentapeptides Phe-(Gly)3-Cys by grafting their cysteine residues to the Pt centers. The resulting CB[8]·(Pt·peptide)2 assemblies were used to target secondary hosts CB[7] and CB[8] via their pair of phenylalanine residues, again in situ. A series of well-defined architectures, including a supramolecular “pendant necklace” with hybrid head-to-head and head-to-tail arrangements inside CB[8], were obtained during the self-sorting process after combining only 3 or 4 simple building units.A platinum terpyridyl complex, pentapeptide Phe-(Gly)3-Cys and cucurbit[8]uril assemble into a “pendant necklace” with hybrid head-to-head and head-to-tail arrangements in aqueous medium. |
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