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Spiropyran‐Conjugated Pluronic as a Dual Responsive Colorimetric Detector
Authors:Yeon Jeong Oh  Jeong A Nam  Abdullah Al‐Nahain  Sangkug Lee  Insik In  Sung Young Park
Abstract:Novel spiropyran‐conjugated Pluronic polyethylene oxide (PEO)‐b‐polypropylene oxide (PPO)‐b‐polyethylene oxide (PEO)] micelles are developed as a new colorimetric detector showing photo‐ or thermo‐switchable behavior. Facile conjugation of spiropyran to Pluronic was confirmed by 1H NMR, UV–Vis, and Fluorescence spectroscopy. A switchable photoluminescence is found depending on the irradiation with either UV or visible light, and temperature resulting from structural isomerization of spiropyran between spiropyran (SP) and merocyanine (MC) form. Cytotoxicity of the spiropyran‐conjugated Pluronic (SP‐PL) was evaluated following an MTT assay, whereas photo responsiveness of spiropyran within the micelles was determined by confocal laser scanning microscopy.
Keywords:biocompatibility  colorimetric  imaging  photo‐switchable  thermo‐switchable
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