Electrochemical monitoring of the interaction of cisplatin with cystine and ascorbic acid |
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| Institution: | 1. Department of Civil & Environmental Engineering, University of Connecticut, 261 Glenbrook Rd Unit 3037, Storrs, CT 06269, USA;2. Center for Clean Energy Engineering, University of Connecticut, 44 Weaver Rd, Storrs, CT 06269, USA;1. Department of Chemistry and Bioengineering, Iwate University, Ueta-4-3-5, Morioka, Iwate, 020-8551, Japan;2. National Institute for Materials Science (NIMS), Namiki 1-1, Tsukuba, Ibaraki, 305-0044, Japan;1. School of Chemistry and Chemical Engineering, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Collaborative Innovation Center of Henan Province for Fine Chemicals Green Manufacturing, Henan Normal University, Xinxiang 453007, P. R. China;2. College of Environmental Science and Engineering, Donghua University, Shanghai 201620, P. R.China;1. Dipartimento di Scienze Chimiche e Farmaceutiche, Via Fossato di Mortara 17-19, Università di Ferrara, 44121 Ferrara, Italy;2. King Pharmaceuticals Inc., Research and Development, 4000 CentreGreen Way, Suite 300, Cary, NC 27513, USA;3. Leiden Academic Centre for Drug Research, Division of Medicinal Chemistry, P. O. Box 9502, 2300 RA Leiden, The Netherlands;4. Dipartimento di Scienze Mediche, Sezione di Farmacologia, Università di Ferrara, Ferrara, Italy |
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| Abstract: | The interaction of cisplatin with cystine (RSSR) and ascorbic acid (AA) has been investigated in aqueous solution at physiological pH, using drug concentration of 0.835×10?6 M to 46.76×10?6 M with RSSR concentration of 6.5×10?5 M by voltammetric techniques. Voltammetric results show that at low drug concentration (<0.835×10?6 M), the interaction between cisplatin and RSSR occurs slightly, while at higher drug concentrations (≥0.835×10?6 M), cisplatin binds to RSSR and gives an unseparated-reduction peak at ?0.610 V. Based on the voltammetric behaviour of RSSR, it has been suggested that binding of cisplatin to RSSR occurs mainly at the disulphide bond. It has been shown that the interaction of cisplatin with RSSR in the presence of AA is very rapid with regards to the interaction without AA, and a new peak, probably corresponding to the interaction of cisplatin with RSSR and AA is appeared at ?0.970 V. The fractional coefficient for the binding of cisplatin to RSSR with or without AA was calculated to be 0.031 and 0.055, respectively. |
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