癌免疫抑制机制的研究——健康人血浆对肝癌等患者细胞免疫的去抑制作用

临床上癌症患者细胞免疫功能下降的原因,多数认为是由于患者血浆中存在“免疫抑制因子”所致,也有部分认为是T淋巴细胞本身缺陷的原因。那么是不是所有的癌症患者血桨中都有这种“抑制因子”呢?我们采用E——玫瑰花结,淋巴细胞转化联合试验为细胞免疫功能的检测指标,对肝癌、肺癌、胃癌、肠癌及其他癌进行研究。发现:肝癌、肺癌及其他癌患者的血浆确有“免疫抑制因子”,因为健康人血桨对肝癌、肺癌及其他癌患者细胞免疫能起去抑制作用。也就是当患者的血桨与正常人血浆互相交换后,患者细胞免疫功能得到回升,而正常人的细胞免疫功能由于癌症患者血浆的存在而有所下降(统计学上有显著意义)。这说明癌症患者细胞免疫功能下降的原因是相当复杂的。患者血浆中的免疫抑制因子只是一方面的原因,有待于今后继续深入研究。

INVESTIGATION OF THE MECHANISM OF THE IMMUNOSUPPRESSION IN CANCER: THE RELIEF OF SERUM INHIBITORY ACTION IN CANCER PATIENS BY THE PLASMA OF NORMAL HEALTHY PERSON

Impairment of cellular immunity in cancer patients was found to be associated with the existence of serum-inhibitory factors in most cases or sometimes only with the appearance of lymphocytes bearing an intrinsic defect. Our study, by the joined test of lymphocytes transformation and rosette formation of sheep red blood cells, also revealed similar results.The patients investigated consisted of cancer of the liver, lung, stomach and intestine, etc. The responsiveness of lymphocytes to PHA and the rate of SRBC rosette formation in cancer patients were significantly lower than that of the normal controls.The effect of cross-matching of the serum from cancer patients on normal lymphocytes or of the serum from normal controls on lymphocytes of cancer patients was investigated. It was found that the rate of responsiveness to PHA and rosette formation of the lymphocytes of cancer patients, except cancer of stomach and intestine, increased significantly when its autologous serum was replaced by the normal serum, while the responsiveness of lymphocytes from normal controls was inhibited significantly by the presence of cancer sera. In the cases of cancer of the stomach and intestine, neither enhanced responsiveness of lymphocytes from cancents was observed by reblacement with normal serum nor diminished resbonsiveness of lymphocytes from normal person was obtained by addition of cancer sera. It seems that the nature of impairment of cellular immunity in cancer patients might be qualitatively different in various conditions, and its characterization is a great challenge lying ahead of us.