Chemo-enzymatic synthesis and biological evaluation of photolabile nicotinic acid adenine dinuclotide phosphate (NAADP+) |
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| Authors: | Parkesh Raman Vasudevan Sridhar R Berry Alexandra Galione Antony Dowden James Churchill Grant C |
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| Affiliation: | Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK. raman.parkesh@pharm.ox.ac.uk |
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| Abstract: | A chemo-enzymatic synthesis of novel caged NAADP+ without the formation of multiple cage compounds has been achieved. The biological activity of the caged NAADP+ was demonstrated by its fast uncaging in intact sea-urchin eggs. |
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