Total synthesis of (+/-)-mitorubrinic acid |
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| Authors: | Marsini Maurice A Gowin Kristoffer M Pettus Thomas R R |
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| Institution: | Department of Chemistry and Biochemistry, University of California at Santa Barbara, Santa Barbara, California 93106, USA. |
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| Abstract: | reaction: see text] (+/-)-Mitorubrinic acid, a member of the azaphilone family of natural products, has been constructed in 12 steps. Key aspects of the synthesis include elaboration and oxidative dearomatization of an isocoumarin intermediate to provide the azaphilone nucleus with a disubstituted, unsaturated carboxylic acid side chain. |
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