Dioxygen-coupled oxidative amination of styrene |
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Authors: | Timokhin Vitaliy I Anastasi Natia R Stahl Shannon S |
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Institution: | Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, WI 53706, USA. |
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Abstract: | Dioxygen-coupled oxidative amination of olefins is an attractive, but challenging, catalytic transformation. The present work describes the first general method for intermolecular oxidative amination of aryl olefins with molecular oxygen as the stoichiometric oxidant. This palladium-catalyzed reactivity is compatible with several different nitrogen nucleophiles, including oxazolidinone, phthalimide, pyrrolidinone, and p-toluenesulfonamide. The presence of a catalytic quantity of a Br?nsted base in the reaction increases the catalytic activity and switches the reaction regioselectivity. |
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