| 三尖杉酯碱侧链酸的不对称合成及结构表征 |
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| 引用本文： | 孙默然,周航,曹其伟,高凯歌,杨华.三尖杉酯碱侧链酸的不对称合成及结构表征[J].化学研究,2013(4):416-419. |
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| 作者姓名： | 孙默然 周航 曹其伟 高凯歌 杨华 |
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| 作者单位： | 郑州大学药学院 |
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| 基金项目： | 国家自然科学基金资助项目(20502023) |
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| 摘 要： | 以N-Boc苏氨醛为起始原料,经Wittig、Meisenheimer重排和催化氢化系列反应,不对称合成了天然产物三尖杉酯碱的侧链酸,中间体及目标产物结构经核磁共振(1 H NMR、13 C NMR)、红外光谱和质谱表征.结果表明,所用合成方法具有产率高、反应条件温和、操作简单等优点;目标化合物的总收率达30%.
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| 关 键 词： | 三尖杉酯碱 侧链酸 不对称合成 结构表征 |
Asymmetric synthesis and structural characterization of side-chain acid of harringtonine |
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| SUN Mo-ran,ZHOU Hang,CAO Qi-wei,Gao Kai-ge,YANG Hua.Asymmetric synthesis and structural characterization of side-chain acid of harringtonine[J].Chemical Research,2013(4):416-419. |
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| Authors: | SUN Mo-ran ZHOU Hang CAO Qi-wei Gao Kai-ge YANG Hua |
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| Institution: | *(School of Pharmaceutical Science,Zhengzhou University,Zhengzhou 450001,Henan,China) |
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| Abstract: | Asymmetric synthesis of harringtonine side-chain acid was accomplished by a sequence of Wittig and Meisenheimer rearrangements plus catalytic hydrogenation reaction in the presence of N-Boc amino aldehyde as the starting material.The structure of the intermediates and as-synthesized target product was characterized by means of nuclear magnetic resonance spectrometry（1 H NMR and 13C NMR）,infrared spectrometry and mass spectrometry.Results indicate that the methods adopted have the advantages of high yield,mild reaction condition,and simple operation,and the overall yield of target compound is as much as 30%. |
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| Keywords: | harringtonine side-chain acid asymmetric synthesis structural characterization |
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