Compatibility
and stability tests of risperidone with soft-drinks by isothermal titration
microcalorimetry |
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Authors: | H Aki Y Okamoto T Kimura |
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Institution: | (1) Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka Japan, 814-0180, 8-19-1 Nanakuma, Jonan-ku;(2) Janssen Pharmaceutical K. K., Shizuoka Japan, 411-0932, 600-8 Minami-isshiki, Nagaizumi-cho, Sunto-gun;(3) Faculty of Science and Technology, Kinki University, Osaka Japan, 577-8502, Kowakae 3-4-1, Higashi-Osaka |
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Abstract: | Isothermal
titration microcalorimetry has been applied to investigate the compatibility
testing of risperidone oral solution with soft-drinks and the interaction
with tea tannin such as (–)-epigallocatechin, (–)-epicatechin,
theaflavin and their gallates. In aqueous solution, risperidone was exothermically
bound to tea tannin with binding affinity (103–104
M–1), small enthalpy and entropy changes
reflecting van der Waal’s interaction to form an insoluble complex at
1:1 molar ratio. The heat effect of risperidone titrated into soft-drinks
containing tannin was exothermic and proportional to the quantity of the complex.
While, no significant heat effect was found for risperidone titrated into
a pet-bottled water and an infusion of parched barley without tea tannin.
These results were agreed with stability testing of risperidone in some soft-drinks
by HPLC method. |
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Keywords: | compatibility epicatechin epigallocatechin isothermal titration microcalorimetry risperidone theaflavin |
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