Micellar electrokinetic chromatography: current developments and future |
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Authors: | Molina Manuel Silva Manuel |
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Institution: | Department of Analytical Chemistry, Edificio Marie Curie (Anexo), Campus de Rabanales, University of Córdoba, Córdoba, Spain. |
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Abstract: | This review highlights recent methodological and instrumental advances in micellar electrokinetic chromatography (MEKC). Enhancements in sensitivity and selectivity of the technique through the use of on-line preconcentration approaches (stacking and sweeping) and nonconventional pseudostationary phases, namely nonionic and zwitterionic surfactants, mixed micelles and polymers, are discussed in detail. Laser-induced fluorescence and mass spectrometry, as alternatives to UV-absorption detection, have been covered to evaluate their advantages and limitations when applied to analysis in an MEKC format. Some thoughts on future directions in this area such as in-capillary reactions, coated capillaries and MEKC on microchips are also presented. |
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