Preconcentration of uric acid at a carbon paste electrode |
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| Affiliation: | 1. Nanomaterial Toxicology Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhawan, 31 Mahatma Gandhi Marg, Lucknow, 226001, Uttar Pradesh, India;2. Department of Chemical Engineering, Indian Institute of Technology Kanpur, Kanpur, 208016, India;3. Center for Environmental Science and Engineering, Indian Institute of Technology Kanpur, Kanpur, 208016, India;1. Key Laboratory of Biologic Resources of Protection and Utilization of Hubei Province, Hubei Minzu University, Enshi, Hubei, 445000, China;2. Department of Chemistry, Hubei Minzu University, Enshi, Hubei, 445000, China;3. College of Chemistry and Chemical Engineering, Luoyang Normal University, Luoyang, 471934, China;1. Department of Organic and Nano Engineering, Hanyang University, Seoul 133-791, Republic of Korea;2. Electrochemical Energy Laboratory, Department of Chemistry, SRM Institute of Science and Technology, Kattankulathur, 603203, India;3. Department of Chemical Engineering, Hanyang University, Seoul 133-791, Republic of Korea;4. Department of Textile Engineering, Mehran University of Engineering and Technology, Jamshoro, 76062, Pakistan |
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| Abstract: | Uric acid is shown to adsorb rapidly on a carbon paste electrode, with the surface species retaining its characteristic electroactivity. Using this phenomenon to preconcentrate uric acid, voltammetric measurements are improved with respect to sensitivity and selectivity. By simply immersing the electrode in the uric acid-containing sample for a given period of time, and then transferring the electrode to an electrolytic blank solution, a high degree of selectivity is achieved. Solution-phase species with similar redox potentials, e.g., ascorbic acid, do not interfere. The differential pulse response is evaluated with respect to concentration dependence, preconcentration period, reproducibility, rotation speed, pH, paste composition, and other variables. The method is exploited for selective detection of uric acid in a flow injection system. Illustrative voltammograms of uric acid in urine and plasma are presented. |
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