| Synthesis of a Polymer-bound Sensitizer and its Application in the Photoisomerization of trans-Vitamin D_3 to cis-Vitamin D_3 |
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| 作者姓名： | Yun Yan GAO Chang Jiang YOU Jin Ping CHEN Yong Yong LIU Bao Wen ZHANG Yi LI* Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing |
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| 作者单位： | Yun Yan GAO，Chang Jiang YOU，Jin Ping CHEN，Yong Yong LIU，Bao Wen ZHANG，Yi LI* Technical Institute of Physics and Chemistry，Chinese Academy of Sciences，Beijing 100101 |
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| 基金项目： | 科技部资助项目，国家自然科学基金，中国科学院资助项目 |
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| 摘 要： | The photochemistry of the vitamin D family and their precursors has been the subject of extensive studies for many years1-4. Most of the studies focus on the photoisomer- ization of 7-dehydrocholesterol and that of tachysterol to previtamin D3, which is of commercial importance in the synthesis of vitamin D34, 5. Recently the cis/trans isomerization of vitamin D analogs (Scheme 1) draws attention because of its importance in the synthesis of hydroxylated vitamin D metabolites6. However, o…
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Synthesis of a Polymer-bound Sensitizer and its Application in the Photoisomerization of trans-Vitamin D3 to cis-Vitamin D3 |
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| Yun Yan GAO,Chang Jiang YOU,Jin Ping CHEN,Yong Yong LIU,Bao Wen ZHANG,Yi LI* Technical Institute of Physics and Chemistry,Chinese Academy of Sciences,Beijing .Synthesis of a Polymer-bound Sensitizer and its Application in the Photoisomerization of trans-Vitamin D_3 to cis-Vitamin D_3[J].Chinese Chemical Letters,2002,13(12). |
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| Authors: | Yun Yan GAO Chang Jiang YOU Jin Ping CHEN Yong Yong LIU Bao Wen ZHANG YI Li |
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| Abstract: | A polymer-bound photosensitizer was synthesized by the reaction of Merrifield resin with 9-anthracenemethanol in the presence of potassium hydride. The photoisomerization of trans-vitamin D3 to cis-vitamin D3 was carried out with this polymer-bound photosensitizer in ethanol and toluene solutions. The experiment results demonstrate that this solid photosensitizer is efficient for the photoismerization and easy for separation from the reaction mixtures. |
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| Keywords: | Photoisomerization solid phase sensitizer vitamin D_3 |
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