| Abstract: | Summary 1. By the azide condensation of fragments followed by the hydrogenolysis of the completely protected nonapeptides formed, the encephalitogenic nonapeptides with the structure Phe-Ser-Try-Gly-Ala-Glu-Gly-Gln-Arc and two of its analogs — the 6-glycine and 5,6-diglycine compounds, have been synthesized.2. It has been shown that the 6-glycine analog induces EAE, i.e., the side chain in position 6 is not essential for the appearance of EAE activity.3. The absence of an encephalitogenic effect in the 5,6-diglycine analog permits the conclusion that the side chain of the alanine-5 makes a contribution to the induction of the disease.4. The N-acetyl derivative of the encephalitogenic nonapeptide retains a high EAE activity.Institute of Molecular Biology and Genetics, Academy of Sciences of the Ukrainian SSR, Kiev. A. V. Palladin Institute of Biochemistry, Academy of Sciences of the Ukrainian SSR, Kiev. Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 507–517, July–August, 1976. |
