A new sensor for electrochemical determination of captopril using chlorpromazine as a mediator at a glassy carbon electrode |
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Authors: | Ali A Ensafi A Arabzadeh |
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Institution: | 1.Department of Chemistry,Isfahan University of Technology,Isfahan,Iran |
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Abstract: | A new simple, selective and rapid cyclic voltammetric method is reported for the accurate and precise determination of captopril
using chlorpromazine as a suitable electrocatalyst. It has been shown by cyclic voltammetry, single step chronoamperometry
and electrochemical impedance spectroscopy that chlorpromazine can catalyze the oxidation of captopril in aqueous buffer solution
and produces a sharp oxidation peak current at about 0.625 V vs. saturated calomel reference electrode. The catalytic oxidation
peak current of captopril is linearly dependent on its concentration and enables the determination of captopril over the concentration
range of 8–1000 μM at pH 5.0, with a detection limit of 4.8 μM. The relative standard deviation for the determination of 400
μM captopril is 0.66% (n = 9). The influence of potential interfering substances on the determination of captopril was studied. The method was satisfactorily
applied to the determination of captopril in real samples such as drug and urine. |
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