首页 | 本学科首页   官方微博 | 高级检索  
     检索      


Liquid Chromatography Analysis of Reactive Oxoammonium Cations
Authors:Rohland  Philip  Schreyer  Kristin  Burges  Rene  Fritz  Nicole  Hager  Martin D  Schubert  Ulrich S
Institution:1.Laboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena, Humboldtstra?e 10, 07743, Jena, Germany
;2.Center for Energy and Environmental Chemistry Jena (CEEC Jena), Friedrich Schiller University Jena, Philosophenweg 7a, 07743, Jena, Germany
;3.Jena Center for Soft Matter (JCSM), Friedrich Schiller University Jena, Philosophenweg 7, 07743, Jena, Germany
;
Abstract:

This study presents the first liquid chromatography method for the quantitative and qualitative analysis of highly reactive oxoammonium cations based on a simple derivatization reaction. Rapid 1,2-electrophilic addition reactions with olefins were used to transform these reactive species into analyzable derivates. Three model substances were chosen to represent each of the main application fields of oxoammonium cations and to demonstrate the versatility of the method. The measuring protocol was validated according to the ICH and USP guidelines. The method revealed an excellent linearity (R2?=?0.9980–0.9990) with a low limit of detection (0.16–0.14 mmol L?1) and a low limit of quantification (0.55–0.43 mmol L?1). The protocol was finally used to determine the oxoammonium cations in the presence of their corresponding radical, showing a robustness against impurity concentration of up to approx. 30%.

Keywords:
本文献已被 SpringerLink 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号