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Development of a microwave-enhanced isotopic labelling procedure based on the Eschweiler–Clarke methylation reaction |
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| Authors: | John R. Harding John R. Jones Shui-Yu Lu Robin Wood |
| Affiliation: | aAstraZeneca UK Ltd, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK bDepartment of Chemistry, University of Surrey, Guildford, Surrey GU2 7XH, UK |
| Abstract: | A number of primary and secondary amines have been rapidly methylated under microwave-enhanced conditions using formic acid-formaldehyde mixtures, providing a route to 2H(D)-containing compounds and the potential for 3H(T), 11C, 13C and 14C labelling. |
| Keywords: | deuterium labelling methylation microwaves |
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