| Abstract: | A novel and convenient method for the synthesis of eritadenine (I) was established. Direct condensation of adenine and 2,3-O-isopropylidene-D -erythronolactone (II) under basic condition, followed by removal of the protecting group, afforded eritadenine (I) in fairly good yield, with accompany of a small amount of the N3-isomer (VI). A similar reaction of adenine 1-oxide gave exclusively eritadenine oxide (VII), which was catalytically reduced to give eritadenine (I). This procedure also provided pyrimidinyl derivatives (VIII, IX and X) corresponding to cytosine, uracil, and thymine. |
