| β-环糊精衍生物与吡罗昔康的包合特性 |
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| 引用本文： | 王茹林,王恩成,秦姝竹,王鹏.β-环糊精衍生物与吡罗昔康的包合特性[J].应用化学,2012,29(8):910-914. |
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| 作者姓名： | 王茹林 王恩成 秦姝竹 王鹏 |
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| 作者单位： | (山西医科大学化学教研室 太原 030001) |
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| 基金项目： | 山西省科技厅自然科学基金(20051029) |
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| 摘 要： | 采用荧光光谱、差热扫描和核磁共振法，研究了不同酸度下吡罗昔康（PX）与β-环糊精（β-CD）、羟丙基-β-环糊精（HP-β-CD）和磺丁醚-β-环糊精（SBE-β-CD）的包合特性。 结果表明，吡罗昔康与3种环糊精均形成了1∶2.5的包合物。 以包合常数为包合能力的量度，中性条件下，包合平衡常数分别为1.2×106、1.8×106、2.0×106，3种环糊精的包合能力为SBE-β-CD＞HP-β-CD＞β-CD。
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| 关 键 词： | 吡罗昔康 &beta -环糊精 荧光光谱 差热扫描 核磁共振 |
| 收稿时间： | 2011-09-06 |
| 修稿时间： | 2011-11-23 |
Inclusion Properties of Piroxicam by β-Cyclodextrin and Its Derivatives |
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| WANG Rulin,WANG Encheng,QIN Shuzhu,WANG Peng.Inclusion Properties of Piroxicam by β-Cyclodextrin and Its Derivatives[J].Chinese Journal of Applied Chemistry,2012,29(8):910-914. |
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| Authors: | WANG Rulin WANG Encheng QIN Shuzhu WANG Peng |
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| Institution: | (The Chemistry Department of Shanxi Medical University,Taiyuan 030001,China) |
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| Abstract: | The inclusion properties of piroxicam(PX) by β-cyclodextrin(β-CD),hydroxypropyl-β-cyclodextrin(HP-β-CD),and sulfobutyl ether-β-cyclodextrin(SBE-β-CD) were studied by fluorescence spectroscopy,differential scanning calorimetry(DSC) and NMR at different pH.The results showed that the 1∶ 2.5 inclusion compounds were formed between piroxicam and CDs.Based on the formation constants,which were 2.0×106,1.8×106,1.2×106 in neutral media,the inclusion capacity showed the order of SBE-β-CD>HP-β-CD>β-CD. |
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| Keywords: | piroxicam β-cyclodextrin fluorescence spectroscopy DSC NMR |
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