| 光学纯反式-(+)-水合蒎醇的新方法合成 |
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| 引用本文： | 汪秋安,罗俊霞,廖头根.光学纯反式-(+)-水合蒎醇的新方法合成[J].高等学校化学学报,2004,25(6):1069-1072. |
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| 作者姓名： | 汪秋安 罗俊霞 廖头根 |
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| 作者单位： | 湖南大学化学化工学院, 化学生物传感与计量学国家重点实验室, 长沙 410082 |
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| 基金项目： | 教育部留学回国人员科研启动基金 (批准号 :教外司留 [2 0 0 2 ] 2 47号 )资助 |
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| 摘 要： | 以3,5-二羟基-4-甲基苯甲酸甲酯为原料,通过7步反应,高产率地合成了反式-(+)-水合蒎醇(+)-1],其结构通过IR,MS和NMR等技术进行了确认,该化合物的光学纯度e.e.高达99%.
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| 关 键 词： | 反式-(+)-水合蒎醇 萜二醇 光学纯度 |
| 文章编号： | 0251-0790(2004)06-1069-04 |
| 收稿时间： | 2003-04-25 |
A Novel Synthesis of Optically Pure trans-(+)- Sobrerol |
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| WANG Qiu-An,LUO Jun-Xia,LIAO Tou-Gen.A Novel Synthesis of Optically Pure trans-(+)- Sobrerol[J].Chemical Research In Chinese Universities,2004,25(6):1069-1072. |
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| Authors: | WANG Qiu-An LUO Jun-Xia LIAO Tou-Gen |
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| Institution: | College of Chemistry and Chemical Engineering, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha 410082, China |
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| Abstract: | A novel and highly efficient synthesis of optically pure \%trans\%-(+)-sobrerol\,starting from methyl 3,5-dihydroxy-4-methyl benzoate(2) in 7 steps with overall yield 27%,was reported. The key intermediate(+)-5 was prepared in remarkably high yield by lipase\_\_catalyzed asymmetrization of 4. A critical step to stereoselectively inverse the configuration of(+)-6 was realized under Mistunobu conditions. The structures of all the compounds were confirmed by IR,MS and NMR spectra. |
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| Keywords: | trans-(+)-Sobrerol Terpinediol Optical purity |
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