A concise synthesis of the pentacyclic framework of cortistatins |
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| Authors: | Yamashita Shuji Iso Kentaro Hirama Masahiro |
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| Institution: | Department of Chemistry, Graduate School of Science, Tohoku University, and Research and Analytical Center for Giant Molecules, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan. s-yamashita@mail.tains.tohoku.ac.jp |
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| Abstract: | An efficient synthesis of the pentacyclic framework of cortistatins has been developed. The key strategy comprises assembly of the A- and the CD-ring fragments by Knoevenagel reaction, facile formation of the pyran ring via electrocyclization, and construction of the seven-membered B-ring by radical addition to an alpha,beta-unsaturated ketone. |
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