Progress toward the total synthesis of frondosin C |
| |
Authors: | Li Xin Kyne Robert E Ovaska Timo V |
| |
Institution: | Department of Chemistry, Connecticut College, 270 Mohegan Avenue, New London, CT 06320, USA. |
| |
Abstract: | A straightforward approach toward the total synthesis of frondosin C is described. This strategy involves a key one-pot, microwave-assisted 5-exo cyclization-Claisen rearrangement sequence that was used for the expedient assembly of the frondosic C scaffold. Subsequent manipulation of the tetracyclic core allowed the synthesis of an advanced intermediate bearing the characteristic diene moiety in the B ring. reaction: see text] |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|