Enantioselective direct-addition of terminal alkynes to imines catalyzed by copper(I)pybox complex in water and in toluene |
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Authors: | Wei Chunmei Li Chao-Jun |
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Institution: | Department of Chemistry, Tulane University, New Orleans, Louisiana 70118, USA. |
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Abstract: | Highly enantioselective direct alkyne-imine additions catalyzed by Cu(I)OTf and Evan's pybox ligands were developed in water and in toluene. The process is simple and provides a diverse range of propargylic amine in high ee and good yield. |
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