Chemo- and regioselective functionalization of uracil derivatives. Applications to the synthesis of oxypurinol and emivirine |
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| Authors: | Boudet Nadège Knochel Paul |
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| Affiliation: | Department Chemie und Biochemie, Ludwig-Maximilians-Universit?t, Butenandtstrasse 5-13, 81377, München, Germany. |
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| Abstract: | [reaction: see text] A novel route for the synthesis of 4,5-difunctionalized uracils using a chemo- and regioselective bromine/magnesium exchange reaction on 5-bromo-4-halogeno-2,6-dimethoxypyrimidines has been developed. Applications to the synthesis of pharmaceuticals such as oxypurinol and emivirine are reported. |
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