| 气相色谱法测定二咖啡酰奎尼酸原料药中的有机溶剂残留量 |
| |
| 引用本文： | 魏君,闫平,娄艳红,谢剑炜. 气相色谱法测定二咖啡酰奎尼酸原料药中的有机溶剂残留量[J]. 光谱实验室, 2009, 26(2): 309-311 |
| |
| 作者姓名： | 魏君 闫平 娄艳红 谢剑炜 |
| |
| 作者单位： | 军事医学科学院毒物药物研究所 北京市海淀区太平路27号6所8室,100850 |
| |
| 摘 要： | 以1,2-二氯乙烷作为内标,气相色谱法定量检测二咖啡酰奎尼酸原料药中7种有机溶剂残留量。色谱柱：DB-624,30m×0.32mm×1.8μm,载气为H2,检测器为FID,采用程序升温的方法。7种残留溶剂的线性关系良好（r〉0.9914）,回收率为92.5%—98.5%,最小检出限量均为0.01%。本方法简便、灵敏、准确,可用于二咖啡酰奎尼酸原料药残留溶剂的质量控制。
|
| 关 键 词： | 气相色谱法 二咖啡酰奎尼酸 残留溶剂 |
Determination of Residual Solvents in Dicaffeoylquinic Substance by Gas Chromatography |
| |
| WEI Jun,YAN Ping,LOU Yan-Hong,XIE Jian-Wei. Determination of Residual Solvents in Dicaffeoylquinic Substance by Gas Chromatography[J]. Chinese Journal of Spectroscopy Laboratory, 2009, 26(2): 309-311 |
| |
| Authors: | WEI Jun YAN Ping LOU Yan-Hong XIE Jian-Wei |
| |
| Affiliation: | Beijing Institute of Pharmacology & Toxicology;Beijing 100850;P.R.China |
| |
| Abstract: | The residual solvents,such as ethonal,acetic ether,acetonitrile,acetone,pyridine,piperidine,acetic acid in dicaffeoylquinic substance were determined by gas chromatography with 1,2-dichloroethane as internal standard,DB-624 capillary column（30m×0.32mm×1.8μm） as analysis column,hydrogen gas as carrier gas and FID as detector. All the results for the standard curve,the recovery and the separation factors showed that the method is satisfied,sensitive,accurate,and suitable for quality control of residual solvents in dicaffeoylquinic substance. |
| |
| Keywords: | Gas Chromatography Dicaffeoylquinic Substance Residual Solvents. |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
