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Synthesis and X-ray structures of new cycloalka[e]pyrano[2,3-b]pyridine derivatives: novel tacrine analogues |
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| Authors: | H. HayourA. Bouraiou,S. BouacidaF. Berré e,B. CarboniT. Roisnel,A. Belfaitah |
| Affiliation: | a Laboratoire des Produits Naturels d’Origine Végétale et de Synthèse Organique, Université Mentouri, Constantine 25000, Algeria b Unité de Recherche de Chimie de l’Environnement et Moléculaire Structurale, Université Mentouri, Constantine 25000, Algeria c Université de Rennes 1, Sciences Chimiques de Rennes, UMR 6226 CNRS, 35042 Rennes Cedex, France d Centre de Diffractométrie X, UMR 6226 CNRS Unité Sciences Chimiques de Rennes, Université de Rennes I, 35042 Rennes Cedex, France |
| Abstract: | A new series of tacrine (9-amino-1,2,3,4-tetrahydroacridine) analogues consisting of a cycloalka[e]pyrano[2,3-b]pyridine linked to a quinolyl ring has been synthesized. These compounds were prepared from the appropriately substituted pyran derivative via a Friedländer reaction with selected cycloalkanones in high yields. Single crystal X-ray structures are reported for four compounds. |
| Keywords: | Quinoline 4H-Pyran Tacrine analogues Friedlä nder reaction |
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