Enantioselective synthesis of spirooxoindoles via chiral auxiliary (bicyclic lactam) controlled SNAr reactions |
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| Authors: | Sen Subhabrata Potti Venkata R Surakanti Ramu Murthy Y L N Pallepogu Raghavaiah |
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| Affiliation: | Medicinal Chemistry Department, GVK Biosciences, Plot 28A, IDA Nacharam, Hyderabad, India. Subhabrata.sen@gvkbio.com |
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| Abstract: | A highly efficient enantioselective S(N)Ar reaction of chiral acyl bicyclic lactam with substituted-2,4-dinitrobenzenes was developed, affording products containing quarternary stereogenic centers. They are further utilized towards an enantioselective synthesis of spirooxoindoles. |
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