Comparison of the use of aqueous and nonaqueous buffers in association with cyclodextrin for the chiral separation of 3,4-methylenedioxymethamphetamine and related compounds |
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Authors: | Huang Yu-San Tsai Chung-Chen Liu Ju-Tsung Lin Cheng-Huang |
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Institution: | Department of Chemistry, National Taiwan Normal University, Taipei, Taiwan. |
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Abstract: | A comparison of the use of aqueous and nonaqueous buffers in association with beta-CD for the chiral separation of (R)- and (S)-3,4-methylenedioxymethamphetamine and related compounds is described. The (R)- and (S)-isomers of 3,4-methylenedioxymethamphetamine (MDMA) and its major metabolite 3,4-methylenedioxyamphetamine (MDA) were prepared. Under aqueous and nonaqueous buffer conditions and based on the CZE and MEKC modes, the order of migration of (R)-MDA, (S)-MDA, (R)-MDMA, and the (S)-MDMA enantioisomers were determined. Several electrophoretic parameters, including the concentration of beta-CD (aqueous, 25-60 mM; nonaqueous, 20-150 mM) used in the electrophoretic separation and the amount of organic solvents required for the separation, were optimized. |
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Keywords: | Aqueous and nonaqueous buffers Capillary electrophoresis Enantioseparation 3 4‐Methylenedioxymethamphetamine |
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