Chlorination of 4-methyl-8-methoxy-2,3-dihydro-1H,1,5-benzodiazepin-2-one |
| |
| Authors: | I A Abronin L G Gorb V G Dryuk V I Sheremet Z F Solomko M M Kremlev |
| |
| Institution: | (1) Dnepropetrovsk Institute of Chemical Technology, 320640 Dnepropetrovsk;(2) Dnepropetrovsk State University, 320625 Dnepropetrovsk |
| |
| Abstract: | The results of the chlorination of 4-methyl-8-methoxy-2,3-dihydro-1H,1,5-benzodiazepin-2-ones are compared with the results of quantum-chemical calculations of 4-methyl-2,3-dihydro-1H-1,5-benzodiazepin-2-ones with various substituents in the benzene ring in the case of homolytic halogenation. The chlorination of 4-methyl-8-methoxy-2,3-dihydro-1H-1,5-benzodiazepin-2-one (I) with N-chlorosuccinimide leads to 3-chloro- and 3,3-dichloro-4-methyl-8-methoxy-2,3-dihydro-1H-1,5-benzodiazepin-2-ones, whereas chlorination with sulfuryl chloride leads to 4-chloromethyl and 3,3-dichloro-4-methyl derivatives. The IR, PMR, and mass spectra of the synthesized compounds are presented.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, pp. 1272–1274, September, 1981. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
