Copper‐Mediated Aromatic 1,1‐Difluoroethylation with (1,1‐Difluoroethyl)trimethylsilane (TMSCF2CH3) |
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Authors: | Xinjin Li Dr Jingwei Zhao Yunze Wang Jian Rong Dr Mingyou Hu Dr Dingben Chen Pan Xiao Dr Chuanfa Ni Prof?Dr Limin Wang Prof?Dr Jinbo Hu |
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Institution: | 1. Key Laboratory of Advanced Materials, Institute of Fine Chemicals, East China University of Science and Technology, Shanghai, China;2. Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China |
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Abstract: | A new method for the formation of 1,1‐difluoroethyl copper species (“CuCF2CH3”) with 1,1‐difluoroethylsilane (TMSCF2CH3) has been developed. The “CuCF2CH3” species can be applied to the efficient 1,1‐difluoroethylation of diaryliodonium salts under mild conditions, affording (1,1‐difluoroethyl)arenes in good to excellent yields. This convenient procedure tolerates a wide range of functional groups and thus serves as a practical synthetic tool for the introduction of CF2CH3 group(s) into complex molecules. |
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Keywords: | fluorinated compounds 1 1-difluoroethyl arenes copper diaryliodonium salts silanes |
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