Synthesis of (±)‐Lasubine II Using N‐Methoxyamines |
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| Authors: | Takashi Yokoyama Yutaro Fukami Dr Takaaki Sato Prof?Dr Noritaka Chida |
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| Institution: | Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan |
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| Abstract: | The synthesis of (±)‐lasubine II has been achieved through a three‐component allylation capitalizing on the unique properties of N‐methoxyamines. This reaction enabled the installation of all the carbon atoms of lasubine II in a single operation. The N‐methoxy group was efficiently used for the subsequent nitrone formation. A single‐step cyclization of isoxazolidines or N‐methoxyamines to form functionalized piperidine rings was also developed. |
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| Keywords: | allylation amines lasubine multicomponent reactions total synthesis |
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